Temperature-sensitive mutants of the foot-and-mouth disease virus exhibit varying physiological defects in RNA and antigen production and can be grouped by genetic recombination.
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Mutant groupings in FMDV are hypothesis-generating; leaves open relevance to viral replication or control strategies.
Summary The physiological defects associated with 17 temperature-sensitive mutants of the kenya 3/57 strain of foot-and-mouth disease virus were examined in terms of the ability of the mutants to produce infective RNA and complementfixing antigen under restrictive conditions. The yields of infective RNA obtained with different mutants ranged from less than 0·31 to 87% of normal, and of complement-fixing antigen from 12·6 to 99·6 % of normal. Genetic recombination was observed in crosses of mutants with different physiological effects, such that the mutants could be arranged in five groups.
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Pringle et al. (1970) studied this question.
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