Why the study?
Does mitral-valve replacement improve pulmonary vascular dynamics in patients with severe mitral-valve disease and pulmonary hypertension?
Does mitral-valve replacement improve pulmonary vascular dynamics in patients with severe mitral-valve disease and pulmonary hypertension?
This study aims to determine the extent to which abnormalities in the pulmonary circulation are reversible following mitral-valve replacement in patients with severe mitral-valve disease and pulmonary hypertension.
Answers are grounded in this paper and cite their sources.
Reversibility of pulmonary vascular abnormalities after mitral-valve replacement in severe disease with PH remains uncertain; leaves open need for definitive prospective data.
THE development of an elevation of the pulmonary vascular resistance is a common complication of severe mitral-valve disease, and this abnormality has been attributed to a combination of obliterative changes in the pulmonary vascular bed and pulmonary vasoconstriction.1 2 3 In many patients the elevation of pulmonary vascular resistance is extreme and constitutes the major hemodynamic burden faced by the right ventricle.4 Under these circumstances the secondary changes in the pulmonary vascular bed become primarily responsible for many of the clinical findings, including ventricular failure. In view of these considerations determination of the extent to which these abnormalities in the pulmonary circulation . . .
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Braunwald et al. (1965) studied this question.
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