Key result
Women with polycystic ovary syndrome (N=64) had greater sympathetic autonomic cardiac modulation during and after consecutive tilt tests compared with controls.
Why the study?
This study aimed to analyze cardiac autonomic modulation using spectral and symbolic analysis of heart rate variability in women with PCOS subjected to two consecutive tilt tests.
Case-Control (n=64)
Answers are grounded in this paper and cite their sources.
Suggests autonomic imbalance in PCOS under repeated stress; leaves open clinical relevance pending prospective studies.
OBJECTIVE: The present study aimed to analyze cardiac autonomic modulation via spectral and symbolic analysis of heart rate variability (HRV) in women with polycystic ovary syndrome (PCOS) who were subjected to two consecutive tilt tests. METHODS: A total of 64 women were selected and divided into 2 groups: control (without PCOS), and PCOS. Concentrations of follicle-stimulating hormone, luteinizing hormone, prolactin, estradiol, homocysteine, sex hormone-binding globulin, thyroid stimulating hormone, fasting insulin, testosterone, androstenedione, and 17-hydroxyprogesterone levels, triglycerides, free androgen index (FAI), and homeostasis assessment model (HOMA-IR) were assessed. Cardiac autonomic modulation was evaluated by spectral and symbolic analyses during two consecutive tilt tests (two moments) and supine moments before, between and after (three moments) the tilt tests. RESULTS: Women with PCOS had higher fasting insulin, HOMA-IR indexes, testosterone and FAI. Additionally, we observed that the PCOS group had greater sympathetic autonomic cardiac modulation in supine 2, tilt 1, and supine 3 moments compared with controls. CONCLUSION: Women with PCOS had higher autonomic sympathetic cardiac modulation even after a second tilt test. No adaptation to this provocative test was observed. Spectral analysis was more sensitive for identifying differences between groups than the symbolic analysis.
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Ribeiro et al. (2020) conducted a case-control in Polycystic ovary syndrome (PCOS) (n=64). Polycystic ovary syndrome (PCOS) vs. Control (without PCOS) was evaluated on Cardiac autonomic modulation via spectral and symbolic analysis of heart rate variability. Women with polycystic ovary syndrome (N=64) had greater sympathetic autonomic cardiac modulation during and after consecutive tilt tests compared with controls.
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