Why the study?
Does Ac-SDKP improve cardiac systolic and diastolic function in spontaneously hypertensive rats?
Does Ac-SDKP improve cardiac systolic and diastolic function in spontaneously hypertensive rats?
Reducing left ventricular collagen deposition with Ac-SDKP in hypertensive rats decreases systolic performance without improving diastolic function, suggesting collagen reduction alone may not benefit cardiac function in hypertensive heart disease.
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Ac-SDKP-mediated collagen normalization fails to improve function in SHR; leaves open whether antifibrotic strategies alone benefit hypertensive heart disease.
Cingolani et al. (2004) studied this question.
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