What question did this study set out to answer?

To evaluate whether cigarette smoking impairs pulsatile arterial function in young, asymptomatic adults who lack other major cardiovascular risk factors.

March 1, 2005American Journal of Hypertension

Vascular abnormalities in asymptomatic, healthy young adult smokers without other major cardiovascular risk factors: The Bogalusa Heart Study

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Why the study?

Does cigarette smoking impair pulsatile arterial function in healthy young adults without other major cardiovascular risk factors?

Population

287 healthy young adults, mean age 36 years, without obesity, hypertension, dyslipidemia, diabetes, or…

Comparison

Cigarette smoking vs Nonsmokers

Design

Cross-sectional

Authors

HLH LIVanderbilt University SSS SRINIVASANMedical University of Vienna WCWei ChenGuiyang College of Traditional Chinese Medicine

Discussion

Member takes

Implication

Smoking may impair early arterial function in healthy young adults; cross-sectional data leave open reversibility and should not yet change practice.

Key Points

To evaluate whether cigarette smoking impairs pulsatile arterial function in young, asymptomatic adults who lack other major cardiovascular risk factors.
Examined 145 nonsmokers and 142 smokers (mean age 36 years) from the Bogalusa Heart Study selected for the absence of obesity, hypertension, dyslipidemia, diabetes, or overt cardiovascular disease.
Assessed large artery compliance (C1), small artery compliance (C2), and systemic vascular resistance (SVR) noninvasively using radial artery waveform recordings.
Smokers demonstrated significantly lower small artery compliance (5.09 vs 6.63 mL/mm Hg x 100, P = .0009) and higher systemic vascular resistance (1399.0 vs 1325.5 dyn · sec · cm⁻⁵, P = .006) compared with nonsmokers after adjustment for race, sex, and age.
Increasing smoking duration correlated with worsening small artery compliance (P for trend = .001; multivariate P = .004) and rising systemic vascular resistance (P for trend = .01).
Smokers had 2.9 times higher odds of falling into the lowest 10th percentile for small artery compliance (P = .01) and 2.6 times higher odds of the highest 10th percentile for systemic vascular resistance (P = .07).

Structured PICO

Does cigarette smoking impair pulsatile arterial function in healthy young adults without other major cardiovascular risk factors?

Population

287 healthy young adults (145 nonsmokers, 142 smokers), mean age 36 years, without obesity, hypertension, dyslipidemia, diabetes, or clinically manifest cardiovascular disease.

Intervention

Cigarette smoking

Comparator

Nonsmokers

Outcome

Pulsatile arterial function measured by large artery compliance (C1), small artery compliance (C2), and systemic vascular resistance (SVR) via noninvasively recorded radial artery waveformssurrogate

Cigarette smoking is associated with impaired small artery compliance and increased systemic vascular resistance in otherwise healthy young adults, highlighting the need for early smoking cessation interventions.

Cite This Study

LI et al. (2005) studied this question.

synapsesocial.com/papers/6a8bd95dc12eaf65c8b21f7c https://doi.org/10.1016/j.amjhyper.2004.10.005

Topics

Hypertension management

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Implication

Smoking may impair early arterial function in healthy young adults; cross-sectional data leave open reversibility and should not yet change practice.