Population
Hepatitis C virus 5' noncoding region sequences from patients with chronic infection and cell culture lines
Design
Preclinical
Authors
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These cell-culture observations on HCV 5' NCR heterogeneity are hypothesis-generating; in vivo studies are needed before any clinical relevance can be assessed.
Heterogeneous sequences in the HCV 5' NCR alter its predicted RNA structure and translation efficiency in different cell types.
Araújo et al. (2009) studied this question.
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