Enzyme-linked immunosorbent assay for detection and identification of coxsackieviruses A
Why the study?
Does a double-antibody ELISA accurately detect and serotype coxsackievirus A antigens in clinical and laboratory specimens?
Population
22 to 23 coxsackievirus A complement fixation antigens, tissue culture fluids, and 11 stool specimens from…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May aid ELISA development for coxsackievirus A detection; leaves open clinical utility pending human validation.
Structured PICO
Does a double-antibody ELISA accurately detect and serotype coxsackievirus A antigens in clinical and laboratory specimens?
P
Population
22 to 23 coxsackievirus A complement fixation antigens, tissue culture fluids, and 11 stool specimens from patients with coxsackievirus A infections
I
Intervention
Double-antibody enzyme-linked immunosorbent assay (ELISA) utilizing type-specific monkey and mouse coxsackievirus antisera
O
Outcome
Detection and serotyping of coxsackievirus A antigenssurrogate
A newly developed double-antibody ELISA can rapidly and accurately detect and serotype coxsackievirus A antigens, offering a useful diagnostic tool for clinical specimens.
Cite This Study
Yolken et al. (1981) studied this question.