Population
Primary dissociated rat aortic or mesenteric arterial smooth muscle cells cultured for 24-72 hours
Design
Preclinical
Authors
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May underlie endothelin vasoconstriction; leaves open translation to intact vessels or human disease.
Endothelin induces a calcium-dependent nonselective cation current in vascular smooth muscle cells, contributing to cell depolarization.
Chen et al. (1991) studied this question.
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