What question did this study set out to answer?

To determine how systolic blood pressure, plasma renin activity, and sodium balance interact during the initial 3-week onset of moderate versus severe two-kidney renal hypertension.

June 1, 1975Circulation Research

Plasma renin and sodium balance during development of moderate and severe renal hypertension in rats.

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Authors

FLF LEENENUniversity of Ottawa WJWybren de JongSemmelweis University

Discussion

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Implication

Animal experiment reveals distinct phases of sodium retention and renin activity in rats, indicating dual mechanisms drive renal hypertension progression.

Key Points

To determine how systolic blood pressure, plasma renin activity, and sodium balance interact during the initial 3-week onset of moderate versus severe two-kidney renal hypertension.
Evaluated rats over a 3-week period following unilateral renal artery clipping with an untouched contralateral kidney, using a 0.25-mm clip for moderate hypertension, a 0.20-mm clip for severe hypertension, or sham surgery.
Tracked systolic blood pressure, basal and late-afternoon peripheral plasma renin activity, clipped renal venous plasma renin activity, and daily sodium balance per gram of weight gain.
Application of 0.25-mm and 0.20-mm clips established moderate (160 to 180 mm Hg) and severe (200 to 230 mm Hg) hypertension, respectively, with sodium retention per gram weight gain significantly exceeding sham controls during days 8 to 10.
Basal peripheral plasma renin activity increased only in rats with a 0.20-mm clip after blood pressure reached 160 to 180 mm Hg, whereas renal venous renin output from the clipped kidney rose proportionally with blood pressure in both clipped groups.
Sodium balance and blood pressure stabilized in rats with a 0.25-mm clip, whereas animals with a 0.20-mm clip transitioned into a negative sodium balance below control levels alongside a secondary rise in blood pressure.

Cite This Study

LEENEN et al. (1975) studied this question.

synapsesocial.com/papers/6a8c06e37239707559bee0bf https://doi.org/10.1161/01.res.36.6.179

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June 1, 1975Circulation Research

Plasma renin and sodium balance during development of moderate and severe renal hypertension in rats.

View Full Paper

Ask AI

Bookmark

Authors

FLF LEENENUniversity of Ottawa WJWybren de JongSemmelweis University

Discussion

Member takes

Implication

Animal experiment reveals distinct phases of sodium retention and renin activity in rats, indicating dual mechanisms drive renal hypertension progression.

Key Points

To determine how systolic blood pressure, plasma renin activity, and sodium balance interact during the initial 3-week onset of moderate versus severe two-kidney renal hypertension.
Evaluated rats over a 3-week period following unilateral renal artery clipping with an untouched contralateral kidney, using a 0.25-mm clip for moderate hypertension, a 0.20-mm clip for severe hypertension, or sham surgery.
Tracked systolic blood pressure, basal and late-afternoon peripheral plasma renin activity, clipped renal venous plasma renin activity, and daily sodium balance per gram of weight gain.
Application of 0.25-mm and 0.20-mm clips established moderate (160 to 180 mm Hg) and severe (200 to 230 mm Hg) hypertension, respectively, with sodium retention per gram weight gain significantly exceeding sham controls during days 8 to 10.
Basal peripheral plasma renin activity increased only in rats with a 0.20-mm clip after blood pressure reached 160 to 180 mm Hg, whereas renal venous renin output from the clipped kidney rose proportionally with blood pressure in both clipped groups.
Sodium balance and blood pressure stabilized in rats with a 0.25-mm clip, whereas animals with a 0.20-mm clip transitioned into a negative sodium balance below control levels alongside a secondary rise in blood pressure.

Cite This Study

LEENEN et al. (1975) studied this question.

synapsesocial.com/papers/6a8c06e37239707559bee0bf https://doi.org/10.1161/01.res.36.6.179

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