Why the study?
Does dietary sodium restriction prevent the development of hypertension and cardiac hypertrophy in a 2K,1C rat model?
Population
Young and adult male Wistar rats with two-kidney, one-clip (2K,1C) hypertension
Comparison
Moderate or severe dietary sodium restriction vs Control diet (101 mumol sodium/g food)
Design
Preclinical
Follow-up
up to 6 weeks
Authors
Loading...
Severe sodium restriction may prevent renovascular hypertension and hypertrophy in this model; hypothesis-generating for human translation.
Does dietary sodium restriction prevent the development of hypertension and cardiac hypertrophy in a 2K,1C rat model?
Severe, but not moderate, dietary sodium restriction prevents the development of renovascular hypertension and associated cardiac hypertrophy in a 2K,1C rat model.
Wilczynski et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: