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June 1, 1980Clinical and Experimental Pharmacology and Physiology

Sodium Balance and Plasma Renin Activity During the Development of Two‐kidney Goldblatt Hypertension in Rats

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Population

Rats with two-kidney, one clip (2KIC) severe hypertension (systolic blood pressure 180 mmHg)

Comparison

Low sodium diet and 0.9% saline to drink vs Normal diet and water to drink

Design

Preclinical

Follow-up

35 days

Authors

ADA. E. DoyleVictor Chang Cardiac Research InstituteSDS. DuffyThe University of Melbourne

Discussion

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Implication

Challenges sodium-depletion link to PRA in 2KIC hypertension; leaves open translation to human renovascular disease.

Structured PICO

P
Population
Rats with two-kidney, one clip (2KIC) severe hypertension (systolic blood pressure 180 mmHg)
I
Intervention
Low sodium diet and 0.9% saline to drink
C
Comparator
Normal diet and water to drink
O
Outcome
Blood pressure, plasma renin activity (PRA), body weight, plasma sodium concentration, and carcass sodium contentsurrogate

In a 2KIC rat model of hypertension, elevated plasma renin activity is not universally present and does not appear to be driven by sodium depletion.

Cite This Study

Doyle et al. (1980) studied this question.

synapsesocial.com/papers/6a815ab80914b5fb8de3fd02https://doi.org/10.1111/j.1440-1681.1980.tb00073.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Changes in the Renin-Angiotensin-Aldosterone System and in Sodium and Potassium Balance during Development of Renal Hypertension in Rats1975 · 31 citations
  2. 2Renin-Angiotensin-Aldosterone System and Sodium Balance in Experimental Renal Hypertension1968 · 57 citations
  3. 3Effect of the angiotensin II blocker 1-Sar-8-Ala-angiotensin II on renal artery clip hypertension in the rat.1975 · 42 citations
  4. 4Hypertension Caused by Salt Loading in the Dog1969 · 224 citations
  5. 5Evidence for the Local Occurrence of Angiotensin II in Rat Kidney and its Modulation by Dietary Sodium Intake and Converting Enzyme Blockade1979 · 86 citations