Why the study?
Does poliovirus infection induce apoptosis in CaCo-2 cells?
Does poliovirus infection induce apoptosis in CaCo-2 cells?
Poliovirus infection induces apoptosis in human enterocyte-like CaCo-2 cells.
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No immediate clinical implications for poliovirus; hypothesis-generating for enterocyte damage mechanisms.
The effects of poliovirus infection in CaCo-2 cells, a human enterocyte-like cell line are described. Infected cells were examined by a combination of techniques, including optical and electron microscopy, cytofluorimetric analysis of DNA content, and DNA agarose gel electrophoresis. Results obtained by the different experimental approaches demonstrate that poliovirus infection in enterocyte-like cells can result in an apoptotic process.
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Ammendolia et al. (1999) studied this question.
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