Hirudin and nitrates inhibit the thrombin-induced release of endothelin from the intact porcine aorta.
Why the study?
Do hirudin and nitrovasodilators inhibit the release of endothelin from intact porcine aortas?
Population
Intact porcine aortas with endothelium
Comparison
Hirudin, nitroglycerin, or 3-morpholinosydnonimine vs Control (absence of these agents)
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Hirudin and nitrovasodilators inhibit thrombin-stimulated endothelin release in porcine aortas; extends in vitro data but leaves open human translation.
Structured PICO
Do hirudin and nitrovasodilators inhibit the release of endothelin from intact porcine aortas?
P
Population
Intact porcine aortas with endothelium
I
Intervention
Hirudin (0.1 micrograms/ml), nitroglycerin (10^-5 M), or 3-morpholinosydnonimine (10^-5 M)
C
Comparator
Control (absence of these agents)
O
Outcome
Spontaneous and thrombin-stimulated release of endothelinsurrogate
Hirudin and nitrovasodilators inhibit thrombin-stimulated endothelin release in porcine aortas, suggesting a mechanism by which these agents modulate endothelial function.
Cite This Study
Boulanger et al. (1991) studied this question.