Key result
A higher lymphocyte-to-C-reactive protein ratio was independently associated with a lower risk of coronary artery disease.
Why the study?
The relationship between the lymphocyte-to-C-reactive protein ratio (LCR), a new systemic immune inflammation index, and the development and severity of CAD was not clear.
Does the lymphocyte-to-C-reactive protein ratio (LCR) correlate with the occurrence and severity of coronary artery disease in patients undergoing coronary angiography?
Observational (n=1,107)
No
Does the lymphocyte-to-C-reactive protein ratio (LCR) correlate with the occurrence and severity of coronary artery disease in patients undergoing coronary angiography?
Answers are grounded in this paper and cite their sources.
A higher lymphocyte-to-C-reactive protein ratio (LCR) is independently associated with a lower risk of occurrence and severity of coronary artery disease, suggesting its potential utility as a simple inflammatory biomarker for risk stratification.
Background: Coronary atherosclerosis is a systemic chronic inflammatory disease. Some laboratory parameters, such as the neutrophils-to-lymphocytes ratio (NLR), platelet-to-lymphocyte ratio (PLR) and the systemic immune inflammation index (SII), were used to assess the degree of inflammation and the severity of coronary artery disease (CAD). The lymphocyte-to-C-reactive protein ratio (LCR) is a new systemic immune inflammation index, and its relationship with the development and severity of CAD is not clear.Methods A total of 1107 patients underwent coronary angiography, including 479 in the control group and 628 in the CAD group. The routine and biochemical indexes in the venous blood of patients in each group before coronary angiography were assessed. LCR, SII, NLR and PLR were calculated, and statistical analysis was performed. Propensity score matching (PSM) and a logistic regression model was used to analyze the relationship between LCR and CAD.Results After PSM, 384 pairs of patients with or without CAD were successfully matched. After median binary classification of all indicators, univariate and multivariate logistic regression analysis showed that platelet was an independent related risk factor and LCR was an independent related protective factor. By the same method, in the coronary heart disease severity group, a total of 212 pairs were successfully matched, and it was finally determined that NLR and PLR were independent related risk factors, and LCR was an independent related protective factor.Conclusions LCR is an independent correlative protective factor affecting the occurrence and severity of CAD.
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Chen et al. (2022) conducted an observational in Coronary artery disease (n=1,107). Lymphocyte-to-C-reactive protein ratio (LCR) vs. Lower LCR was evaluated on Presence of coronary artery disease (OR 0.635, 95% CI 0.477-0.845, p=0.002). A higher lymphocyte-to-C-reactive protein ratio was independently associated with a lower risk of coronary artery disease.
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