September 1, 1996Journal of Biological ChemistryOpen Access

Role of Malignant Hyperthermia Domain in the Regulation of Ca2+ Release Channel (Ryanodine Receptor) of Skeletal Muscle Sarcoplasmic Reticulum

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Population

Skeletal muscle ryanodine receptor (RYR) / triad vesicles

Design

Preclinical

Authors

FZFrancesco ZorzatoElectrophysiology PMPaola MenegazziUniversity of Ferrara STSusan TrevesUniversity of Ferrara

Discussion

Member takes

Implication

mAb419 offers a probe for RyR Ca2+ regulation in vitro; leaves open translation to cardiac disease models.

Structured PICO

Population

Skeletal muscle ryanodine receptor (RYR) / triad vesicles

Intervention

Monoclonal antibody 419 (mAb419) targeting a sequence upstream from Gly341 of the skeletal muscle ryanodine receptor

Outcome

Ca2+-induced Ca2+ release rate and [3H]ryanodine bindingsurrogate

Monoclonal antibody 419 stimulates ryanodine receptor channel activity by perturbing an intramolecular interaction between the immunopositive polypeptide and a Ca2+ regulatory site.

Cite This Study

Zorzato et al. (1996) studied this question.

synapsesocial.com/papers/6a8c1d451692ae2bc0f47e08 https://doi.org/10.1074/jbc.271.37.22759

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Role of Malignant Hyperthermia Domain in the Regulation of Ca2+ Release Channel (Ryanodine Receptor) of Skeletal Muscle Sarcoplasmic Reticulum

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of Malignant Hyperthermia Domain in the Regulation of Ca2+ Release Channel (Ryanodine Receptor) of Skeletal Muscle Sarcoplasmic Reticulum

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider