Lower leg skeletal muscle function may contribute to exercise capacity through an indirect mechanism on cardiac function in heart failure.
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Suggests lower leg muscle function may indirectly influence exercise capacity in HF; leaves open the causal.
BACKGROUND: Skeletal muscle pump function may play a key role in maintaining cardiac output (CO), because of the lack of cardiac contractility reserve during incremental exercise in heart failure (HF) patients. We aimed to investigate the relationship between lower leg pump function and surrogate measures of CO during cardiopulmonary exercise testing (CPX) in HF patients. METHODS AND RESULTS: pulse (β=0.520, P<0.001) in HF patients. CONCLUSIONS: Lower leg skeletal muscle function may contribute to exercise capacity through an indirect mechanism on cardiac function in HF.
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Kondo et al. (2018) studied this question.
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