April 1, 1985The Journal of Cell Biology
Effect of viral infection on host protein synthesis and mRNA association with the cytoplasmic cytoskeletal structure.
Population
Normal and virus-infected eucaryotic cells
Comparison
Viral infection vs Normal cells and other conditions inhibiting…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for cytoskeletal mRNA roles in viral translation control; leaves open relevance to human cells or other pathogens.
Structured PICO
P
Population
Normal and virus-infected eucaryotic cells
I
Intervention
Viral infection (poliovirus, vesicular stomatitis virus, reovirus)
C
Comparator
Normal (uninfected) cells and other conditions inhibiting protein synthesis
O
Outcome
Association of eucaryotic viral and cellular mRNAs with cytoskeletal fractions and protein synthesissurrogate
The association of mRNA with the cytoskeletal framework is required but not sufficient for protein synthesis, and poliovirus shuts off host protein synthesis by uniquely releasing host mRNAs from the cytoskeleton.
Cite This Study
Bonneau et al. (1985) studied this question.