April 1, 1996Clinical and Applied Thrombosis/Hemostasis

Antithrombin Concentrates in Heparin-Resistant Cardiopulmonary Bypass Patients

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Why the study?

Does antithrombin concentrate improve activated clotting time in heparin-resistant patients undergoing cardiopulmonary bypass?

Population

12 patients undergoing cardiopulmonary bypass surgery who were considered heparin resistant

Design

Case_series

Authors

MIMehraboon S. IraniVersiti Blood Center of Wisconsin

Discussion

Member takes

Implication

May support antithrombin for heparin-resistant CPB; leaves open efficacy, safety, and need for RCTs.

Structured PICO

Does antithrombin concentrate improve activated clotting time in heparin-resistant patients undergoing cardiopulmonary bypass?

Population

12 patients undergoing cardiopulmonary bypass surgery (CPB) who were considered heparin resistant (activated clotting time not >400 s after >300 U/kg of heparin)

Intervention

Antithrombin concentrates

Outcome

Activated clotting time (ACT) prolongation to >400 ssurrogate

Antithrombin concentrate effectively prolongs activated clotting time in heparin-resistant patients undergoing cardiopulmonary bypass, offering a potential alternative to excessive heparin or fresh frozen plasma.

Cite This Study

Mehraboon S. Irani (1996) studied this question.

synapsesocial.com/papers/6a8d461760a354c5ab7fe647 https://doi.org/10.1177/107602969600200204

View Full Paper

Ask AI

Bookmark

Antithrombin Concentrates in Heparin-Resistant Cardiopulmonary Bypass Patients

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Antithrombin Concentrates in Heparin-Resistant Cardiopulmonary Bypass Patients

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider