Why the study?
Due to the correlation of inflammation with PCSK9 and EAT enlargement, researchers evaluated whether PCSK9 was expressed in EAT and associated with EAT inflammation and volume.
Population
Patients undergoing surgery from whom EAT samples were isolated
Design
Observational cross-sectional study
Key result
PCSK9 expression in epicardial adipose tissue was positively associated with EAT thickness and local proinflammatory mediators, independent of circulating PCSK9 levels.
Authors
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Suggests a local, tissue-specific role for PCSK9 in epicardial inflammation independent.
Observational
PCSK9 is locally expressed in epicardial adipose tissue and correlates with local inflammation and tissue thickness, suggesting a potential local role in cardiovascular risk independent of circulating levels.
Dozio et al. (2020) reported an observational. PCSK9 expression in epicardial adipose tissue was evaluated on Association of PCSK9 expression with EAT thickness and local proinflammatory mediators. PCSK9 expression in epicardial adipose tissue was positively associated with EAT thickness and local proinflammatory mediators, independent of circulating PCSK9 levels.
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