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This review discusses the mechanisms of vascular smooth muscle contraction, including calcium-insensitive pathways, and the rationale for using calcium channel blockers in hypertension.
This review outlines the mechanisms of vascular smooth muscle contraction and provides a pathophysiological rationale for the use of calcium channel blockers in hypertension.
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Supports mechanistic rationale for calcium channel blockers; leaves open clinical relevance of calcium-insensitive pathways.
It is generally acknowledged that calcium plays a major role in the generation of vascular tone. However, in recent years it has become increasingly evident that relatively calcium-insensitive pathways of excitation-contraction coupling also exist in the vascular smooth muscle cell. Possible mechanisms of vascular smooth muscle contraction and their possible role in the pathophysiology of hypertension are reviewed. The rationale for the use of calcium channel blockers in the treatment of hypertension is discussed. Am J Hypertens 1990;3:291S-298S
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Morgan et al. (1990) conducted a review in Hypertension. Calcium channel blockers was evaluated. This review discusses the mechanisms of vascular smooth muscle contraction, including calcium-insensitive pathways, and the rationale for using calcium channel blockers in hypertension.
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