Key points are not available for this paper at this time.
Design
Review
Answers are grounded in this paper and cite their sources.
Provides rationale for CCBs in hypertension; leaves open prospective validation of calcium-insensitive pathways.
It is generally acknowledged that calcium plays a major role in the generation of vascular tone. However, in recent years it has become increasingly evident that relatively calcium-insensitive pathways of excitation-contraction coupling also exist in the vascular smooth muscle cell. Possible mechanisms of vascular smooth muscle contraction and their possible role in the pathophysiology of hypertension are reviewed. The rationale for the use of calcium channel blockers in the treatment of hypertension is discussed.
No takes yet. Share an insight, caveat, or question.
Morgan et al. (1990) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: