Nitric oxide plays a key mechanistic role in the cardiovascular instability and acute hypotension observed during haemodialysis.
Nitric oxide pathways may contribute to intradialytic hypotension; leaves open whether targeted modulation improves outcomes.
Acute hypotension is a major cardiovascular complication of haemodialysis. The cardiac output falls but the total peripheral resistance remains unchanged at the time when hypotension develops. Nitric oxide affects myocardial contraction and noradrenergic response, and regulates vascular tone. This review discusses the mechanisms of acute hypotension occurring during haemodialysis, focusing on the role of nitric oxide in the associated cardiovascular instability.
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Yokokawa et al. (1996) studied this question.
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