January 1, 1980CirculationOpen Access

Constrasts and similarities of acute hemodynamic responses to specific antagonism of angiotensin II (Sar1, Thr8 A II) and to inhibition of converting enzyme (captopril).

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Why the study?

Does captopril have different acute hemodynamic and blood pressure effects compared to [Sar1, Thr8] A II in hypertensive patients?

Population

23 hypertensive patients

Comparison

Captopril (converting enzyme inhibitor) vs [Sar1, Thr8] A II

Design

Other

Follow-up

acute (early)

Authors

FFF. M. FouadUniversity Medical Center Groningen JCJoanne CeimoUniversity of Arizona RTRobert C. TaraziGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Captopril may confer greater acute MAP reduction than AII antagonism alone; leaves open additional mechanisms in hypertension.

Structured PICO

Does captopril have different acute hemodynamic and blood pressure effects compared to [Sar1, Thr8] A II in hypertensive patients?

Population

23 hypertensive patients

Intervention

Captopril (converting enzyme inhibitor)

Comparator

[Sar1, Thr8] A II (specific angiotensin II antagonist)

Outcome

Early changes in mean arterial pressure (MAP) and hemodynamics (cardiac output, systemic resistance)surrogate

Captopril produces a greater acute reduction in mean arterial pressure than specific angiotensin II antagonism in hypertensive patients, suggesting an additional vasodilator effect.

Cite This Study

Fouad et al. (1980) studied this question.

synapsesocial.com/papers/6a9016ef743786549a0410bf https://doi.org/10.1161/01.cir.61.1.163

Topics

Hypertension management

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Bookmark

Constrasts and similarities of acute hemodynamic responses to specific antagonism of angiotensin II (Sar1, Thr8 A II) and to inhibition of converting enzyme (captopril).

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Constrasts and similarities of acute hemodynamic responses to specific antagonism of angiotensin II (Sar1, Thr8 A II) and to inhibition of converting enzyme (captopril).

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider