Why the study?
Do bronchodilator drugs prevent changes in pulmonary resistance and compliance in experimental lung embolism in guinea-pigs?
Do bronchodilator drugs prevent changes in pulmonary resistance and compliance in experimental lung embolism in guinea-pigs?
Bronchodilator drugs such as salbutamol can prevent adverse pulmonary mechanical changes induced by experimental micro-embolism in a guinea-pig model.
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Should not alter clinical embolism management; hypothesis-generating for bronchodilator effects on pulmonary mechanics in animal models.
In the anaesthetized guinea-pig micro-embolism induced by barium sulphate causes marked increases in pulmonary resistance and decreases in pulmonary compliance. Bronchodilator drugs prevent these changes with salbutamol showing much greater activity on pulmonary resistance changes than compliance changes. The results are discussed with regard to the site of action in the respiratory tree and potential clinical use.
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M J Daly (1974) studied this question.
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