AMV reverse transcriptase can deacylate Trp-tRNA in the presence of viral 35 S RNA, which may increase the efficiency of in vivo assembly of viral genomes carrying an endogenous primer.
Tryptophanyl-tRNA can be used as a primer for RNA-dependent DNA synthesis by avian reverse transcriptase. We have determined that whereas the retroviral polymerase is not by itself capable of deacylating Trp-tRNATrp, the ester linkage between the 3' OH of the ribose moiety and the aminoacid can be very efficiently hydrolyzed when both the polymerase and the viral 35 S RNA are present.
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Sarih et al. (1982) studied this question.
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