Why the study?
Does amiodarone suppress inducible ventricular arrhythmias in dogs with myocardial infarction, and how does it relate to myocardial concentration?
Does amiodarone suppress inducible ventricular arrhythmias in dogs with myocardial infarction, and how does it relate to myocardial concentration?
High-dose amiodarone producing high myocardial concentrations failed to suppress sustained ventricular arrhythmias in a canine post-MI model, whereas a lower dose was effective.
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High-dose amiodarone failed to suppress inducible VT/VF in post-MI dogs unlike low-dose; leaves open non-linear dose-response for further study.
Abdollah et al. (1991) studied this question.
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