Population
Skinned left ventricular epicardial muscle strips from 5 human hearts with mitral regurgitation heart…
Comparison
Sinusoidal length perturbation analysis vs Nonfailing (NF) control hearts
Design
Preclinical
Authors
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Longer prerigor crossbridge dwell time may compensate in MR yet impair EF; hypothesis-generating for molecular therapies, prospective validation required.
In human mitral regurgitation, a longer prerigor crossbridge dwell time may act as a compensatory mechanism for tension maintenance while potentially contributing to reduced elastance and ejection fraction.
Mulieri et al. (2002) studied this question.
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