The first complete genome sequence of a novel CVB3 strain from a monkey with severe myocarditis provides a resource for understanding its evolutionary characteristics and molecular pathogenesis.
Novel CVB3 genome from primate myocarditis; leaves open translational relevance to human disease while extending pathogenesis resources.
Coxsackievirus B3 (CVB3) is an enterovirus in the family Picornaviridae that is significant to human health, being associated with myocarditis, aseptic meningitis, and pancreatitis, among other conditions. In addition to humans, Sichuan snub-nosed monkeys can be infected and killed by CVB3. Here, we report the first complete genome sequence of a novel coxsackievirus B3 strain, SSM-CVB3, which was isolated from a deceased Sichuan snub-nosed monkey with severe myocarditis. Our findings may aid in understanding the evolutionary characteristics and molecular pathogenesis of this virus.
No takes yet. Share an insight, caveat, or question.
He et al. (2012) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: