A notable proportion (20.9%) of U.S. Army recruits lacked neutralizing antibodies to at least one poliovirus type, with higher susceptibility associated with younger age, less education, and northeastern U.S. residence.
May signal immunity gaps among young adults; leaves open need for targeted serosurveillance and vaccination assessment.
Titers of neutralizing antibody to poliovirus types 1, 2, and 3 were determined for serum specimens obtained from 268 U.S. Army recruits. Among those tested, 20.9% lacked neutralizing antibody to one or more types of poliovirus, and 1.1% lacked antibody to all three types. An analysis of demographic data showed that age of less than 18 years, schooling for less than 10 years, and residence in the northeastern United States were associated with higher percentages of recruits lacking neutralizing antibodies to polioviruses in serum.
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Burke et al. (1979) studied this question.
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