Why the study?
Does combined systemic and intra-incisional antibiotic prophylaxis reduce surgical site infection compared to systemic prophylaxis alone in general surgery patients?
Does combined systemic and intra-incisional antibiotic prophylaxis reduce surgical site infection compared to systemic prophylaxis alone in general surgery patients?
Combined systemic and intra-incisional antibiotic prophylaxis was associated with a significantly lower cost of treatment compared to systemic prophylaxis alone in general surgery patients.
Historical observations on surgical infections remain foundational; extends evidence base for modern prevention without altering current practice.
A number of observations by nineteenth-century physicians and investigators were critical to our current understanding of the pathogenesis, prevention, and treatment of surgical infections. In 1846, Ignaz Semmelweis, a Magyar physician, took a post at the Allgemein Krankenhaus in Vienna. He noticed that the mortality from puerperal (
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Inderchand et al. (2021) studied this question.
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