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February 10, 2010Journal of Cardiac Surgery

Band Occlusion of the Atrial Appendage

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Why the study?

Does an expandable polyester fabric-covered silicone band effectively occlude broad-based atrial appendages in a pig model?

Population

6 pigs (pig model) with broad-based right atrial appendages

Design

Preclinical

Follow-up

12 weeks

Authors

ASA. David SlaterLurie Children's HospitalJFJessica L. FoleyLPLynette Phillips

Discussion

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Overview

Should not yet change LAA occlusion practice; leaves open human translation of expandable bands.

Structured PICO

Does an expandable polyester fabric-covered silicone band effectively occlude broad-based atrial appendages in a pig model?

P
Population
6 pigs (pig model) with broad-based right atrial appendages
I
Intervention
Expandable polyester fabric-covered silicone band placed on the right atrial appendage via right thoracotomy
O
Outcome
Feasibility of occlusion, band stability, and healing (smooth surface devoid of thrombus) at 12 weekssurrogate

A novel expandable polyester fabric-covered silicone band effectively and safely occludes broad-based atrial appendages in a porcine model, suggesting feasibility for human LAA occlusion.

Cite This Study

Slater et al. (2010) studied this question.

synapsesocial.com/papers/6a908c646bfd95d7bd4df4bchttps://doi.org/10.1111/j.1540-8191.2009.00989.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left Atrial Appendage Occlusion Pilot Study of a Fourth-Generation, Minimally Invasive Device2012 · 2 citations
  2. 2The New 3D Printed Left Atrial Appendage Closure with a Novel Holdfast Device: A Pre-Clinical Feasibility Animal Study2016 · 12 citations
  3. 3First in vivo evaluation of a flexible self‐apposing left atrial appendage closure device in the canine model2013 · 7 citations
  4. 4Transcatheter occlusion of the left atrial appendage—Experimental testing of a new amplatzer device2010 · 51 citations
  5. 5Epicardial left atrial appendage occlusion with a new medical device: assessment of procedural feasibility, safety and efficacy in a large animal model2020 · 7 citations