January 1, 1997Journal of Cardiovascular Pharmacology

Dissociation Between the Increase in Systemic Vascular Resistance Induced by Acute Nitric Oxide Synthesis Inhibition and the Decrease in Cardiac Output in Anesthetized Dogs

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Why the study?

Does sodium nitroprusside or iloprost prevent the decrease in cardiac output induced by acute nitric oxide synthesis inhibition in anesthetized dogs?

Structured PICO

Does sodium nitroprusside or iloprost prevent the decrease in cardiac output induced by acute nitric oxide synthesis inhibition in anesthetized dogs?

Population

Anesthetized dogs (n=25)

Intervention

Short-term administration of N omega-nitro-L-arginine methyl ester (L-NAME) (0.01-10.0 mg/kg) combined with sodium nitroprusside (1 microgram/kg/min) or iloprost (50 ng/kg/min)

Comparator

L-NAME alone

Outcome

Cardiac output (cardiac index) and systemic vascular resistance (index of systemic vascular resistance)surrogate

The decrease in cardiac output following acute nitric oxide synthesis inhibition is not primarily driven by the concurrent increase in systemic vascular resistance.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not support SVR-targeted interventions to preserve CO after acute NO inhibition; leaves open primary mechanisms and precludes clinical extrapolation.

Cite This Study

Zappellini et al. (1997) studied this question.

synapsesocial.com/papers/6a90e39e5d48fdaeb8cae688 https://doi.org/10.1097/00005344-199701000-00007

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Implication

Does not support SVR-targeted interventions to preserve CO after acute NO inhibition; leaves open primary mechanisms and precludes clinical extrapolation.

Dissociation Between the Increase in Systemic Vascular Resistance Induced by Acute Nitric Oxide Synthesis Inhibition and the Decrease in Cardiac Output in Anesthetized Dogs

Structured PICO

Discussion

Implication

Cite This Study

Dissociation Between the Increase in Systemic Vascular Resistance Induced by Acute Nitric Oxide Synthesis Inhibition and the Decrease in Cardiac Output in Anesthetized Dogs

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider