Why the study?
Does general anesthesia alter hepatic metabolic rate as measured by antipyrine half-life in surgical patients?
Does general anesthesia alter hepatic metabolic rate as measured by antipyrine half-life in surgical patients?
General anesthesia, including enflurane, does not appear to consistently alter hepatic metabolic rate as measured by antipyrine half-life.
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General anaesthesia shows inconsistent antipyrine half-life changes; leaves open any effect on hepatic metabolic rate in surgical patients.
The antipyrine (phenazone) half-life was determined in 20 surgical patients to discover whether there are changes in hepatic metabolic rate during or immediately after anaesthesia compared with the pre-anaesthetic rate. Nine patients received enflurane (mean duration 8.6, SD 2.0 hours) and six patients had a balanced anaesthetic without enflurane (duration 4.4, SD 3.3 hours). A further five patients received a spinal anaesthetic with bupivacaine. The changes in antipyrine half-life were inconsistent, and there was no evidence of competitive metabolic inhibition by general anaesthesia. Antipyrine half-lives did not correlate with serum fluoride levels or urinary fluoride excretion in the case of enflurane. The mean serum inorganic fluoride concentration rose to 29 mumol/litre, and two patients had potentially nephrotoxic concentrations (64 and 50 mumol/litre) after 8 hours of exposure to enflurane though without any evident harmful effects.
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Oikkonen et al. (1984) studied this question.
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