Why the study?
Does the dose of enflurane affect its metabolism to inorganic fluoride in healthy adult male surgical patients?
Population
26 healthy adult male surgical patients (19 received enflurane, 7 received halothane)
Comparison
Enflurane as a supplement to muscle relaxant and… vs Halothane
Design
RCT, Patients receiving enflurane were randomly allocated to three groups
Follow-up
48 hours
Authors
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Enflurane yields sub-nephrotoxic fluoride levels up to 2 MAC hours; confirms dose-dependent metabolism and supports safe use in healthy males.
Does the dose of enflurane affect its metabolism to inorganic fluoride in healthy adult male surgical patients?
Enflurane metabolism to inorganic fluoride is dose-dependent but does not reach nephrotoxic levels even after 2 MAC hours in healthy adult males.
Lowry et al. (1977) studied this question.
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