March 30, 1999Circulation
Sympathetic Rhythmicity in Cardiac Transplant Recipients
Why the study?
Does heart transplantation reverse the dysfunction in autonomic modulation seen in severe heart failure?
Population
27 subjects closely matched for age, sex, and body mass index.
Comparison
Heart transplantation (status) vs Chronic heart failure and normal physiology
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Heart transplant may partially restore autonomic modulation despite high MSNA; leaves open prognostic impact and need for prospective studies.
Structured PICO
Does heart transplantation reverse the dysfunction in autonomic modulation seen in severe heart failure?
P
Population
27 subjects (9 heart transplant recipients, 9 chronic heart failure patients, and 9 normal control subjects) closely matched for age, sex, and body mass index.
I
Intervention
Heart transplantation (status)
C
Comparator
Chronic heart failure and normal physiology (control subjects)
O
Outcome
Resting muscle sympathetic nerve activity (MSNA) and R-R interval variability (spectral analysis of low and high frequency oscillations)surrogate
Heart transplantation restores normal low-frequency oscillatory patterns in sympathetic nerve activity, despite an overall increase in sympathetic drive.
Cite This Study
Borne et al. (1999) studied this question.