Why the study?
Does intermittent insulin therapy improve autonomic neuropathy in streptozotocin diabetic rats?
Population
Streptozotocin diabetic rat model
Comparison
Insulin administered subcutaneously twice daily vs Untreated streptozotocin diabetic rats
Design
Preclinical
Follow-up
2 weeks
Authors
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Does not support clinical use in diabetic autonomic neuropathy; hypothesis-generating for intermittent insulin effects on axonal regeneration in rat models.
Does intermittent insulin therapy improve autonomic neuropathy in streptozotocin diabetic rats?
Intermittent insulin therapy in streptozotocin diabetic rats promotes regenerative changes and reduces degenerative changes in autonomic neuropathy.
Monckton et al. (1982) studied this question.
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