Why the study?
Does the ACE gene insertion/deletion polymorphism predict heart weight in autopsied patients?
Population
443 autopsied patients, excluding those with valvular disease, myocardial infarction, or cardiomyopathy
Comparison
ACE DD genotype vs ACE ID and II genotypes
Design
Cross-sectional
Authors
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ACE DD genotype associated with higher heart weight; hypothesis-generating and should not yet change practice.
Does the ACE gene insertion/deletion polymorphism predict heart weight in autopsied patients?
The ACE DD genotype is an independent predictor of increased cardiac mass, although it is less influential than epigenetic factors such as hypertension or age.
Nakahara et al. (2000) studied this question.
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