Acute Thrombotic Obstruction of Mitral Valve Prosthesis: Low Protein C Level

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Population

A 51-year-old female with acute thrombotic obstruction of a mechanical mitral valve prosthesis despite…

Design

Case_report

Authors

Discussion

Protein C/S deficiency may underlie mechanical valve thrombosis despite anticoagulation; single case leaves open need for prospective validation.

Population

A 51-year-old female with acute thrombotic obstruction of a mechanical mitral valve prosthesis despite adequate anticoagulation with warfarin.

Intervention

Redo mitral valve replacement with a pericardial bioprosthesis.

Low protein C and S levels may contribute to acute thrombotic obstruction of mechanical heart valves even with adequate anticoagulation.

Ohata et al. (2002) studied this question.

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Protein C/S deficiency may underlie mechanical valve thrombosis despite anticoagulation; single case leaves open need for prospective validation.