Why the study?
Does H1- or H2-receptor blockade alter neuroendocrine and cardiovascular responses to central hypovolemia induced by head-up tilt in humans?
Population
7 human males
Comparison
Histamine H1-receptor antagonist mepyramine or… vs Saline infusion
Design
Other
Authors
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H1 but not H2 blockade shortens normotension during head-up tilt; hypothesis-generating for histaminergic sympathoadrenal activation in humans.
Does H1- or H2-receptor blockade alter neuroendocrine and cardiovascular responses to central hypovolemia induced by head-up tilt in humans?
Histaminergic mechanisms are involved in the activation of the sympathoadrenal system, but not the pituitary-adrenal axis, during central hypovolemia in humans.
Matzen et al. (1992) studied this question.
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