Key result
The T235 allele at the M235T polymorphism of the angiotensinogen gene was significantly overtransmitted in Chinese siblings with hypertension (P=0.036).
Why the study?
Are angiotensinogen gene polymorphisms (M235T, T174M, G-217A) associated with hypertension in Chinese siblings?
Population
126 families with a hypertensive proband, including 434 siblings (178 hypertensive), Hong Kong Chinese.
Design
Cross-sectional
Authors
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Does not support genetic testing or practice change; leaves open need for prospective replication in Asians.
Observational (n=434)
Are angiotensinogen gene polymorphisms (M235T, T174M, G-217A) associated with hypertension in Chinese siblings?
p-value: p=0.036
The M235T and T174M variants of the angiotensinogen gene, particularly the T235 allele, are associated with an increased risk of hypertension in Chinese patients.
Fang et al. (2010) conducted an observational in Hypertension (n=434). Angiotensinogen gene polymorphisms (M235T, T174M, and G-217A) was evaluated on Transmission of genetic polymorphism loci related to hypertension (p=0.036). The T235 allele at the M235T polymorphism of the angiotensinogen gene was significantly overtransmitted in Chinese siblings with hypertension (P=0.036).
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