Population
Isolated, lumen-collapsed, S2 segments of the rabbit proximal tubule
Comparison
Cellular acidosis induced by high Pco2 or low… vs Baseline/control conditions
Design
Preclinical
Authors
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Fall in cell pH may drive proximal tubule swelling with K+ uptake in rabbits; leaves open relevance to human renal injury.
In rabbit proximal tubule cells, a fall in cell pH induces cell swelling that is coupled with an accumulation of potassium, with the balancing anions depending on the method used to induce acidosis.
Sullivan et al. (1991) studied this question.
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