January 1, 1987Pacing and Clinical Electrophysiology

Defibrillation Threshold: A Simple and Quantitative Estimate of the Ability to Defibrillate

View Full Paper

Ask AI

Bookmark

Why the study?

Does the defibrillation threshold accurately estimate the ability to defibrillate as defined by a dose-response curve in a porcine model?

Population

12 open chest, halothane anesthetized pigs with electrically induced ventricular fibrillation

Design

Preclinical, Random administration of five different stored voltage levels

Authors

MRMax F. RattesUniversity of Ottawa DJDouglas L. JonesElectrophysiology ASArjun D. SharmaSutter Health

Discussion

Member takes

Implication

DFT offers a rapid surrogate for defibrillation efficacy in porcine models; leaves open human translation and clinical threshold optimization.

Structured PICO

Does the defibrillation threshold accurately estimate the ability to defibrillate as defined by a dose-response curve in a porcine model?

Population

12 open chest, halothane anesthetized pigs with electrically induced ventricular fibrillation

Intervention

Determination of defibrillation threshold followed by random administration of 5 different stored voltage levels distributed around the threshold

Outcome

Relationship of defibrillation threshold to the defibrillation dose-response curve (percentage of defibrillation success)surrogate

Defibrillation threshold is a rapid and quantitative method to estimate defibrillation efficacy, correlating with approximately 76% success on a full dose-response curve.

Cite This Study

Rattes et al. (1987) studied this question.

synapsesocial.com/papers/6a925d9869d1d35888676448 https://doi.org/10.1111/j.1540-8159.1987.tb05926.x

View Full Paper

Ask AI

Bookmark

January 1, 1987Pacing and Clinical Electrophysiology

Defibrillation Threshold: A Simple and Quantitative Estimate of the Ability to Defibrillate

View Full Paper

Ask AI

Bookmark

Why the study?

Does the defibrillation threshold accurately estimate the ability to defibrillate as defined by a dose-response curve in a porcine model?

Population

12 open chest, halothane anesthetized pigs with electrically induced ventricular fibrillation

Design

Preclinical, Random administration of five different stored voltage levels

Authors

MRMax F. RattesUniversity of Ottawa DJDouglas L. JonesElectrophysiology ASArjun D. SharmaSutter Health

Discussion

Member takes

Implication

DFT offers a rapid surrogate for defibrillation efficacy in porcine models; leaves open human translation and clinical threshold optimization.

Structured PICO

Does the defibrillation threshold accurately estimate the ability to defibrillate as defined by a dose-response curve in a porcine model?

Population

12 open chest, halothane anesthetized pigs with electrically induced ventricular fibrillation

Intervention

Determination of defibrillation threshold followed by random administration of 5 different stored voltage levels distributed around the threshold

Outcome

Relationship of defibrillation threshold to the defibrillation dose-response curve (percentage of defibrillation success)surrogate

Defibrillation threshold is a rapid and quantitative method to estimate defibrillation efficacy, correlating with approximately 76% success on a full dose-response curve.

Cite This Study

Rattes et al. (1987) studied this question.

synapsesocial.com/papers/6a925d9869d1d35888676448 https://doi.org/10.1111/j.1540-8159.1987.tb05926.x

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark