April 29, 2003Journal of Hypertension

Intraluminal pressure increases vascular neuronal nitric oxide synthase expression

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Why the study?

Does increased intraluminal pressure increase nNOS expression in rat carotid arteries?

Structured PICO

Does increased intraluminal pressure increase nNOS expression in rat carotid arteries?

Population

Carotid arteries from normotensive rats maintained in an organ culture system

Intervention

High intraluminal pressure (200 mmHg) for up to 24 hours

Comparator

Normal intraluminal pressure (80 mmHg)

Outcome

Expression of neuronal nitric oxide synthase (nNOS) and other NOS isoforms determined by Western blot analysissurrogate

Transmural pressure increases nNOS expression and NO release in rat smooth muscle cells via the MAPK pathway, independent of local angiotensin II formation.

Discussion

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Implication

Pressure-induced nNOS upregulation in rodent vessels is ERK-dependent and Ang II-independent; leaves open relevance to human hypertension or remodeling.

Cite This Study

Ebrahimian et al. (2003) studied this question.

synapsesocial.com/papers/6a925fc84cea2826bc6c48b3 https://doi.org/10.1097/00004872-200305000-00018

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Implication

Pressure-induced nNOS upregulation in rodent vessels is ERK-dependent and Ang II-independent; leaves open relevance to human hypertension or remodeling.

Intraluminal pressure increases vascular neuronal nitric oxide synthase expression

Structured PICO

Discussion

Implication

Cite This Study

Intraluminal pressure increases vascular neuronal nitric oxide synthase expression

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider