Why the study?
Does a rapid antigen detection kit using optical immunoassay accurately detect influenza virus compared to virus isolation and PCR in suspected outpatients?
Does a rapid antigen detection kit using optical immunoassay accurately detect influenza virus compared to virus isolation and PCR in suspected outpatients?
FLU OIA is an easy and quick rapid diagnosis kit for influenza, though it has relatively low specificity due to difficulty in differentiating weak-positive and negative cases.
We investigated the usefulness of a rapid antigen detection kit using optical immunoassay for influenza virus (FLU OIA, BioStar, USA). Nasal aspirates were taken from 92 influenza suspected outpatients between March to April of 1999. Compared with virus isolation and PCR, the sensitivity of FLU OIA was 88.5% and 81.6%, and the specificity was 65.2% and 72.2%. All isolated viruses were influenza type B virus. It was difficult to differentiate the weak-positive and negative cases, leading to the rather low specificity, although the assay procedure was easy and quick. FLU OIA may be a useful rapid diagnosis kit for influenza in pediatric outpatient clinics and wards, because it can detect both influenza type A and type B viruses.
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Komiyama et al. (1999) studied this question.
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