Key result
The FLU OIA test had a significantly lower positivity rate (41.5%) compared to cell culture (55.2%, P=0.009) and RT-PCR (55.9%, P=0.004) for detecting influenza A virus from throat swab specimens.
Why the study?
Does the FLU OIA test accurately detect influenza viruses compared to cell culture and RT-PCR in subjects with flu-like illness?
Population
146 throat swab specimens from subjects with a flu-like illness
Comparison
FLU OIA test (rapid optical immunoassay) vs Cell culture and reverse transcription-PCR
Design
Cross-sectional
Authors
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Caution against sole reliance on FLU OIA for influenza A; leaves open its diagnostic role versus culture or RT-PCR.
Cross-Sectional (n=146)
Yes
Does the FLU OIA test accurately detect influenza viruses compared to cell culture and RT-PCR in subjects with flu-like illness?
Absolute Event Rate: 41.5% vs 55.2%
p-value: p=0.009
The FLU OIA test has a significantly lower positivity rate for detecting influenza A compared to cell culture and RT-PCR.
Boivin et al. (2001) conducted a cross-sectional in Flu-like illness (n=146). FLU OIA test vs. Cell culture and RT-PCR was evaluated on Rate of positivity for influenza detection (p=0.009). The FLU OIA test had a significantly lower positivity rate (41.5%) compared to cell culture (55.2%, P=0.009) and RT-PCR (55.9%, P=0.004) for detecting influenza A virus from throat swab specimens.
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