Why the study?
Does sidestream cigarette smoke exposure alter baroreflex function in spontaneously hypertensive and normotensive rats?
Does sidestream cigarette smoke exposure alter baroreflex function in spontaneously hypertensive and normotensive rats?
Short-term exposure to sidestream cigarette smoke alters autonomic control of heart rate, affecting sympathetic and parasympathetic components in both normotensive and hypertensive rat models.
SSCS exposure alters autonomic heart rate control in rat models; leaves open whether passive smoking affects baroreflex function in humans.
We evaluated short-term effects of sidestream cigarette smoke (SSCS) exposure on baroreflex function in spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) normotensive rats. Rats were exposed to SSCS during three weeks, 180 min, five days per week, in a concentration of carbon monoxide (CO) between 100 and 300 ppm. We observed that SSCS exposure increased tachycardic peak and heart rate range while it attenuated bradycardic reflex in WKY. In respect to SHR, SSCS also increased tachycardic peak. Taken together, our data suggests that three weeks of exposure to SSCS affects the sympathetic and parasympathetic component of the baroreflex in normotensive WKY while it tended to affect the sympathetic component in SHR.
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Valenti et al. (2010) studied this question.
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