Key result
Angiotensin II induced proliferation of murine medullary thick ascending limb of Henle's loop cells in a dose-dependent manner, an effect blocked by the AT1-receptor antagonist losartan.
Population
Murine SV40-transformed renal epithelial cell line derived from medullary thick ascending limb of Henle's loop
Comparison
Angiotensin II (ANG II) vs Control or cells treated with AT1/AT2 receptor…
Design
Preclinical
Authors
Loading...
Should not change losartan use; leaves open Ang II's role in TAL remodeling in hypertension.
Angiotensin II acts as a mitogen for medullary thick ascending limb cells in vitro, demonstrating distinct growth behavior compared to proximal tubular cells.
Wolf et al. (1995) studied this question. Angiotensin II (ANG II) was evaluated on Cell proliferation. Angiotensin II induced proliferation of murine medullary thick ascending limb of Henle's loop cells in a dose-dependent manner, an effect blocked by the AT1-receptor antagonist losartan.