Key result
Anesthesia and surgery were associated with a three-fold increase in plasma renin activity at the midpoint of surgical procedures, with the highest levels in patients receiving the lowest fluid amounts.
Why the study?
Does anesthesia and surgery affect plasma renin activity in surgical patients?
Population
31 surgical patients
Comparison
Anesthesia and surgery vs Baseline (before pre-anesthesia)
Design
Cohort
Follow-up
post-operatively
Authors
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Fluid strategies may blunt surgical renin activation; hypothesis-generating and requires randomized confirmation before practice change.
Observational (n=31)
Does anesthesia and surgery affect plasma renin activity in surgical patients?
Effect estimate: three-fold increase
Surgical stress increases plasma renin activity three-fold, an effect that appears to be modified by intraoperative fluid administration and blood volume changes.
Robertson et al. (1972) conducted an observational in Surgical patients (n=31). Anesthesia and surgery vs. Baseline (before pre-anesthesia) was evaluated on Plasma renin activity (PRA) levels (three-fold increase). Anesthesia and surgery were associated with a three-fold increase in plasma renin activity at the midpoint of surgical procedures, with the highest levels in patients receiving the lowest fluid amounts.
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