Key result
Adding adenosine diphosphate (ADP) to platelet suspensions results in further ADP release by the platelets, inducing subtle nucleotide changes that may be important in platelet aggregation.
Why the study?
Does the addition of adenosine diphosphate (ADP) to platelet suspensions alter nucleotide concentrations?
Does the addition of adenosine diphosphate (ADP) to platelet suspensions alter nucleotide concentrations?
The addition of ADP to platelet suspensions induces further release of ADP, highlighting a mechanism that may be important in platelet aggregation.
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Highlights potential ADP feedback in platelet aggregation; leaves open relevance to human thrombosis or antiplatelet strategies.
Turtle et al. (1965) studied this question. Adding adenosine diphosphate (ADP) to platelet suspensions results in further ADP release by the platelets, inducing subtle nucleotide changes that may be important in platelet aggregation.
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