Key result
Type 2 human poliovirus was exclusively localized within neurons and their processes in the spinal cord of infected mice, supporting the hypothesis of viral dissemination via axonal transport.
The exclusive localization of human poliovirus in neuronal cell bodies, axons, and synaptic elements strongly supports the hypothesis that the virus disseminates in the central nervous system via axonal transport.
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Supports axonal transport hypothesis in murine models; leaves open relevance to human poliovirus pathogenesis and CNS therapies.
Ultrastructural immunohistochemistry was used to localize type 2 human poliovirus (HPV 2) during virulent infection of mice caused by the Lansing strain. In the spinal cord, immune-reaction product was exclusively localized within neurons and their processes. The absence of viral antigen in glial, endothelial and inflammatory cells further supports the strict neuronotropicity of HPV. In addition, viral antigen and virus-like particles were localized in synaptic complexes and axons, including preterminal axons. This clear demonstration of HPV in neuronal cell bodies, their axons, and synaptic elements strongly supports the hypothesis of HPV dissemination in the central nervous system via axonal transport.
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Canto et al. (1986) studied Type 2 human poliovirus (HPV 2) infection. Ultrastructural immunohistochemistry was evaluated on Localization of type 2 human poliovirus. Type 2 human poliovirus was exclusively localized within neurons and their processes in the spinal cord of infected mice, supporting the hypothesis of viral dissemination via axonal transport.
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